03182cam a22003732 b45000010008000000030008000080050017000160060019000330070015000520080041000670200018001080200082001260240018002080350026002260370013002520400029002650500010002940820019003042100067003232450067003902600072004573000032005295060043005615201799006045210053024037000024024567000027024807000043025077000036025507000045025869420012026319990017026439520148026609291839BD-DhUL20150203080450.0m        d        cr  n         110421e20110428xxka     |||||||| 2|eng|d  a9781849731317  a1849731314 (Trade Cloth)cUSD 192.00 Retail Price (Ingram Publisher Services)3 a9781849731317  a(WaSeSS)ssj0000578463  b00154291  aBIP USdBD-DhULcBD-DhUL 4aTD19300a572.8222bNUC10aNucleic Acid Biosensors for Environmental Pollution Monitoring10aNucleic Acid Biosensors for Environmental Pollution Monitoring  aCambridge ;aLaVergne : bRoyal Society of Chemistry, cApril 2011.  ax, 176 p. :bill. ;e22 cm.  aLicense restrictions may limit access.8 aAnnotationbNucleic acids are the fundamental building blocks of life and are found in all living things. In recent years, their functions have been shown to extend beyond the Watson-Crick base pair recognition of complementary strands. Molecules (known as aptamers) consisting of 40-50 nucleotides have been isolated that are able to bind a broad range of molecules with high affinity and specificity. The molecules recognized by aptamers range from small organic molecules to proteins, cells and even intact viral particles. Catalytic DNA molecules called NAzymes (RNAzyme or DNAzyme) have also been shown to exist and, when combined with aptamers, are known as aptazymes. These biomolecules can be used to develop smart and innovative biosensors for environmental analysis. Monitoring of contaminants in the air, water and soil is a key component in understanding and managing risks to human health and ecosystems. This, in conjunction with the time and cost involved in traditional chemical analysis, means there is a growing need for simple, rapid, cost-effective and portable screening methods. Biosensors are compact devices which complement current field screening and monitoring methods. This book demonstrates the incredible opportunities that nucleic acids can offer to environmental analytical chemistry. The chapters: show how nucleic acids have a pivotal role in the development of smart biosensors for environmental monitoring; describe the development of biosensors based on aptamers and NAzymes for the detection of organic and inorganic pollutants; deal with the use of nucleic acid based biosensors for environmental toxicity screening, and detail the use of nanomaterials, as well as miniaturization and lab-on-a-chip technologies, for nucleic acid based biosensing systems.  aCollege AudiencebThe Royal Society of Chemistry1 aMascini, Marcoeed.1 aPalchetti, Ilariaeed.1 aOzsos, Mehmet S.eContribution by4oth1 aErdem, A.eContribution by4oth1 aMarrazza, GiovannaeContribution by4oth  2ddccBK  c19344d19344  00102ddc406572_800000000000000_NUC708NFIC937096aDUSLbDUSLcGENd2012-11-27ePurchasedo572.8 NUCp476726r2014-11-17t1w2014-11-17yBK