El-Metwally, Sara. creator Ouda, Osama M. author. Helmy, Mohamed. author. SpringerLink (Online service) text nyu 2014 monographic eng

electronic

xii, 118 p. : ill. ; 23 cm. The introduction of Next Generation Sequencing (NGS) technologies resulted in a major transformation in the way scientists extract genetic information from biological systems, revealing limitless insight about the genome, transcriptome and epigenome of any species. However, with NGS, came its own challenges that require continuous development in the sequencing technologies and bioinformatics analysis of the resultant raw data and assembly of the full length genome and transcriptome. Such developments lead to outstanding improvements of the performance and coverage of sequencing and improved quality for the assembled sequences, nevertheless, challenges such as sequencing errors, expensive processing and memory usage for assembly and sequencer specific errors remains major challenges in the field. This book aims to provide brief overviews the NGS field with special focus on the challenges facing the NGS field, including information on different experimental platforms, assembly algorithms and software tools, assembly error correction approaches and the correlated challenges. Sara El-Metwally, Osama M. Ouda, Mohamed Helmy. Includes bibliographical references License restrictions may limit access. Life sciences Human genetics Bioinformatics Biological models Life Sciences Systems Biology Human Genetics Bioinformatics QH301-705 570 ELN 9781493907151 9781493907144 (print) 9781493907144 http://www.columbia.edu/cgi-bin/cul/resolve?clio10818114.001 http://www.columbia.edu/cgi-bin/cul/resolve?clio10818114.002 http://www.columbia.edu/cgi-bin/cul/resolve?clio10818114.001 http://www.columbia.edu/cgi-bin/cul/resolve?clio10818114.002 License restrictions may limit access. 140601 20160929141512.0 10818114