Side reactions in peptide synthesis / (Record no. 247157)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05537cam a2200589Ki 4500 |
| 001 - CONTROL NUMBER | |
| control field | ocn920551933 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20190328114812.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cnu---unuuu |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150909t20152016enk o 001 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | OPELS |
| Language of cataloging | eng |
| Description conventions | rda |
| -- | pn |
| Transcribing agency | OPELS |
| Modifying agency | YDXCP |
| -- | OCLCF |
| -- | N$T |
| -- | IDEBK |
| -- | EBLCP |
| -- | OCLCQ |
| -- | ESU |
| -- | DEBBG |
| -- | B3G |
| -- | BRA |
| -- | MERUC |
| -- | COS |
| -- | COF |
| -- | U3W |
| -- | D6H |
| -- | ESEHU |
| -- | AU@ |
| -- | OCLCQ |
| -- | WYU |
| -- | OCLCA |
| -- | MERER |
| -- | OCLCO |
| -- | OCLCA |
| -- | OCLCQ |
| 066 ## - CHARACTER SETS PRESENT | |
| Alternate G0 or G1 character set | (S |
| 019 ## - | |
| -- | 1066447827 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780128011812 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0128011815 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 9780128010099 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 0128010096 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)920551933 |
| Canceled/invalid control number | (OCoLC)1066447827 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QP552.P4 |
| 060 00 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER | |
| Classification number | 2016 A-909 |
| 060 10 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER | |
| Classification number | QU 68 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | SCI |
| Subject category code subdivision | 007000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 572/.65 |
| Edition number | 23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Yang, Yi, |
| Relator term | author. |
| 245 10 - TITLE STATEMENT | |
| Title | Side reactions in peptide synthesis / |
| Medium | [electronic resource] |
| Statement of responsibility, etc. | Yi Yang. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | London, UK : |
| Name of producer, publisher, distributor, manufacturer | Academic Press is an imprint of Elsevier, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2015. |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | �2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction. |
| 500 ## - GENERAL NOTE | |
| General note | Includes index. |
| 588 0# - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Title details screen (ScienceDirect, viewed September 9, 2015). |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Linkage | 880-01 |
| Formatted contents note | Cover; Title Page; Copyright Page; Dedication; Contents; Preface; Chapter 1 -- Peptide Fragmentation/Deletion Side Reactions; 1.1 -- Acidolysis of peptides containing N-Ac-N-alkyl-Xaa motif; 1.2 -- des-Ser/Thr impurities induced by O-acyl isodipeptide Boc-Ser/Thr(Fmoc-Xaa)-OH as building block for peptide synthesis; 1.3 -- Acidolysis of -N-acyl-N-alkyl-Aib-Xaa- bond; 1.4 -- Acidolysis of -Asp-Pro- bond; 1.5 -- Autodegradation of peptide N-terminal H-His-Pro-Xaa- moiety; 1.6 -- Acidolysis of the peptide C-terminal N-Me-Xaa; 1.7 -- Acidolysis of peptides with N-terminal FITC modification. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 3.3 -- Formation of Trp-EDT and Trp-EDT-TFA adduct in peptide global deprotection3.4 -- Trp dimerization side reaction during peptide global deprotection; 3.5 -- Trp reduction during peptide global deprotection; 3.6 -- Cys alkylation during peptide global deprotection; 3.7 -- Formation of Cys-EDT adducts in peptide global deprotection reaction; 3.8 -- Peptide sulfonation in side chain global deprotection reaction; 3.9 -- Premature Acm cleavage off Cys(Acm) and Acm Sb2s!O migration during peptide global deprotection. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 3.10 -- Methionine alkylation during peptide side chain global deprotection with DODT as scavenger3.11 -- Thioanisole-induced side reactions in peptide side chain global deprotection; References; Chapter 4 -- Peptide Rearrangement Side Reactions; 4.1 -- Acid catalyzed acyl Nb2s! migration and the subsequent peptide acidolysis; 4.2 -- Base catalyzed acyl Ob2s! migration; 4.3 -- His-Nim- induced acyl migration; References; Chapter 5 -- Side Reactions Upon Amino Acid/Peptide Carboxyl Activation; 5.1 -- Formation of N-acylurea upon peptide/amino acid-carboxyl activation by DIC. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 5.8 -- Peptide chain termination through the formation of peptide N-terminal urea in CDI-mediated coupling reaction. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes bibliographical references and index. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Peptides |
| General subdivision | Synthesis. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Peptides |
| General subdivision | Synthesis. |
| Source of heading or term | fast |
| Authority record control number | (OCoLC)fst01057580 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | SCIENCE |
| General subdivision | Life Sciences |
| -- | Biochemistry. |
| Source of heading or term | bisacsh |
| 650 12 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Peptide Biosynthesis. |
| Authority record control number | (DNLM)D010452 |
| 650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Peptides |
| General subdivision | chemistry. |
| Authority record control number | (DNLM)D010455Q000737 |
| 650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Drug-Related Side Effects and Adverse Reactions. |
| Authority record control number | (DNLM)D064420 |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 655 #0 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic book. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Materials specified | ScienceDirect |
| Uniform Resource Identifier | http://www.sciencedirect.com/science/book/9780128010099 |
| 880 8# - ALTERNATE GRAPHIC REPRESENTATION | |
| Linkage | 505-00/(S |
| a | 1.8 -- Acidolysis of thioamide peptide1.9 -- Deguanidination side reaction on Arg; 1.10 -- DKP (2,5-diketopiperazine) formation; References; Chapter 2 -- (Sb(B-Elimination Side Reactions; 2.1 -- (Sb(B-Elimination of Cys sulfhydryl side chain; 2.2 -- (Sb(B-Elimination of phosphorylated Ser/Thr; References; Chapter 3 -- Peptide Global Deprotection/Scavenger-Induced Side Reactions; 3.1 -- Tert-butylation side reaction on Trp during peptide global deprotection; 3.2 -- Trp alkylation by resin linker cations during peptide cleavage/global deprotection. |
| 880 8# - ALTERNATE GRAPHIC REPRESENTATION | |
| Linkage | 505-01/(S |
| a | 5.2 -- Uronium/Guanidinium salt coupling reagents-induced amino group guanidination side reactions5.3 -- (Se(B-lactam formation upon Arg activation reaction; 5.4 -- NCA formation upon Boc/Z-Amino acid activation; 5.5 -- Dehydration of side chain-unprotected Asn/Gln during carboxyl-activation; 5.6 -- Formation of H-(Sb(B-Ala-OSu from HOSu-carbodiimide reaction during amino acid carboxyl-activation; 5.7 -- Benzotriazinone ring opening and peptide chain termination during carbodiimide/HOOBt mediated coupling reactions. |
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